![]() ![]() What condition presents with splenomegaly with portal HTN and splenic infarcts, and normocytic anemia with teardrop cells, and thrombocytosis in 50% of cases? Myelofibrosis - growth and proliferation of abnl bone marrow stem cells -> replacement of bone marrow with fibrous connective tissue. Philadelphia chromosome (9q & 22q) in 95% of cases. LAP (leukocyte alkaline phosphatase) decreased. ![]() ![]() ![]() Infection/bleeding uncommon b/c WBCs and platelets retain normal fxn. What condition presents with B sx's (fatigue, night sweats, low-grade fever), mature WBCs but extreme leukocytosis (>200k), and basophilia? CML - massive overproduction of myeloid cells. What condition presents with fatigue from anemia in a child (newborn-14yo), and presence of TdT? ALL - has both TdT and common ALL antigen (CALLA). Bone marrow biopsy showing >30% blasts -> acute leukemia.Ĭhemo tx: cytosine arabinoside (AraC) + either daunorubicin or idarubicin. What's a plasma cell dyscrasia with clonal IgM production? Waldenstrom macroglobulinemia What's a T-cell lymphoma with a predilection for affecting the skin, less commonly the internal organs? Mycosis fungoides What condition presents with fatigue from anemia, bone marrow biopsy showing >30% blasts, Auer rods, myeloperoxidase, and esterase? AML (Auer rods in cytosol, MPO, & esterase). ![]()
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